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Publication
A associação entre periodontite e doença de Alzheimer: revisão narrativa
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 38309 | 1.17 MB | Adobe PDF |
Advisor(s)
Abstract(s)
A doença de Alzheimer (DA) é uma doença neurodegenerativa caracterizada pela perda neuronal precoce, é a primeira causa de demência no mundo.
A Periodontite é uma doença inflamatória de origem infecciosa. Desta forma, os mediadores inflamatórios podem penetrar na circulação sanguínea, causando efeitos sistémicos e podendo contribuir para várias doenças sistémicas como artrite reumatoide, diabetes mellitus ou doenças cardiovasculares e além disso, eles podem também contribuir para a progressão da doença de Alzheimer.
A bactéria Porphyromonas Gingivalis, uma bactéria anaeróbia gram negativa presente na cavidade oral e responsável pela doença periodontal, também pode entrar na corrente sanguínea e chegar ao cérebro, contribuindo para a inflamação e o dano aos neurónios. Isso pode explicar uma possível conexão entre essas duas doenças.
O objetivo desta revisão narrativa é perceber a possível associação entre a periodontite e a doença de Alzheimer.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by early neuronal loss and is the leading cause of dementia worldwide. Periodontitis is an inflammatory disease of infectious origin. In this way, inflammatory mediators can enter the bloodstream, causing systemic effects and may contribute to various systemic diseases such as rheumatoid arthritis, diabetes mellitus, or cardiovascular disease, and furthermore, they may also contribute to the progression of Alzheimer's disease. The bacterium Porphyromonas Gingivalis, a gram-negative anaerobic bacterium present in the oral cavity and responsible for periodontal disease, can also enter the bloodstream and reach the brain, contributing to inflammation and damage to neurons. This may explain a possible connection between these two diseases. The purpose of this narrative review is to understand the possible association between periodontitis and Alzheimer's disease.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by early neuronal loss and is the leading cause of dementia worldwide. Periodontitis is an inflammatory disease of infectious origin. In this way, inflammatory mediators can enter the bloodstream, causing systemic effects and may contribute to various systemic diseases such as rheumatoid arthritis, diabetes mellitus, or cardiovascular disease, and furthermore, they may also contribute to the progression of Alzheimer's disease. The bacterium Porphyromonas Gingivalis, a gram-negative anaerobic bacterium present in the oral cavity and responsible for periodontal disease, can also enter the bloodstream and reach the brain, contributing to inflammation and damage to neurons. This may explain a possible connection between these two diseases. The purpose of this narrative review is to understand the possible association between periodontitis and Alzheimer's disease.
Description
Keywords
Periodontitis Alzheimer's disease Porphyromonas gingivalis Periodontal disease