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Glucagon-like peptide 1: biochemistry, secretion and main physiological effects

2009Journal article Open access
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dc.contributor.authorSilva, Amélia M.
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorMisler, Stanleypor
dc.contributor.authorCooper, Gregory D.por
dc.contributor.authorAndreani, Tatiana
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2010-02-23T15:32:51Zpor
dc.date.accessioned2011-10-06T14:52:39Z
dc.date.available2010-02-23T15:32:51Zpor
dc.date.available2011-10-06T14:52:39Z
dc.date.issued2009por
dc.description.abstractO “Glucagon-like peptide 1” (GLP-1), hormona produzida nas células-L intestinais por processamento diferencial do proglucagon, é libertado após ingestão de alimentos. Efeitos de GLP- 1 observam-se, essencialmente, a nível gastrintestinal e pancreático resultando da sua acção directa, ligação ao receptor nas células alvo, ou indirecta, por regulação parácrina. Pelo seu papel na regulação da ingestão de alimentos e na secreção de insulina induzida por glicose, agonistas do receptor de GLP-1 são alvo de estudos para a terapia da obesidade e diabetes. The peptide hormone Glucagon-like peptide 1 (GLP-1), produced in the intestinal L-cells by differential processing of proglucagon, is secreted in response to meal intake. GLP-1 affects various systems, the gastrointestinal and pancreatic systems being the best studied, either by direct binding to the GLP-1 receptor, at the target-cells surface, or indirectly as a result of paracrine regulation. Because of GLP-1’s roles, in augmenting glucose-induced insulin secretion and modulating food intake, currently GLP-1 receptor agonists are being studied for diabetes and obesity therapy.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 6 (2009) 104-113.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/1275por
dc.language.isoengpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries6por
dc.subjectHormona peptídicapor
dc.subjectGLP-1por
dc.subjectIncretinapor
dc.subjectDiabetes mellitus tipo 2por
dc.subjectObesidadepor
dc.subjectPeptide hormonepor
dc.subjectGlucagon-like peptide 1por
dc.subjectIncretinpor
dc.subjectObesitypor
dc.titleGlucagon-like peptide 1: biochemistry, secretion and main physiological effectspor
dc.typejournal article
dspace.entity.typePublication
person.familyNameSilva
person.familyNameLopes
person.familyNameAndreani
person.familyNameSouto
person.givenNameAmélia
person.givenNameCarla
person.givenNameTatiana
person.givenNameEliana B.
person.identifier447329
person.identifier1251023
person.identifier.ciencia-id241E-3956-0242
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-idF71E-31F5-DF0A
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0002-7524-9914
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0002-3794-8159
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridJ-7128-2013
person.identifier.ridM-4689-2016
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id35578752300
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id36656962100
person.identifier.scopus-author-id8839435500
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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FCS - Número 06 (2009)