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Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres

2009-08Journal article Restricted access
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dc.contributor.authorAraújo, J.
dc.contributor.authorVega, E.
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorEgea, M.A.
dc.contributor.authorGarcia, M.L.
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2020-09-28T15:53:49Z
dc.date.available2020-09-28T15:53:49Z
dc.date.issued2009-08
dc.date.updated2020-07-24T17:28:40Z
dc.description.abstractPoly(lactide-co-glycolide) acid (PLGA) nanospheres incorporating flurbiprofen (FB) were produced by the solvent displacement technique, for ocular applications aiming to avoid/minimize inflammation induced by surgical trauma. In this work, a PLGA of low viscosity has been tested and the results obtained were compared with those previously reported by Vega et al. The physicochemical properties of the developed formulations were evaluated by measuring particle size, zeta potential and FB entrapment efficiency, showing no significant differences. Release studies demonstrated that the formulation produced with PLGA of higher viscosity revealed a slower drug release rate. Stability analysis, for a period of 75 days, was performed using three complementary methods: (i) turbidity experiments using a Turbiscan optical analyzer, (ii) particle size measurements, and (iii) zeta potential analysis. The results revealed long-term physicochemical stability suitability for ophthalmic use, being independent from the polymer viscosity. The ocular tolerance was assessed by an alternative in vitro method to animal experimentation, the HETCAM. For all developed formulations no ocular irritancy has been detected.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.colsurfb.2009.03.028pt_PT
dc.identifier.eid2-s2.0-67349194262
dc.identifier.issn0927-7765
dc.identifier.slugcv-prod-1252845
dc.identifier.urihttp://hdl.handle.net/10284/9006
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectFlurbiprofenpt_PT
dc.subjectPoly(lactic-co-glycolic) acid (PLGA)pt_PT
dc.subjectInherent viscositypt_PT
dc.subjectNanospherespt_PT
dc.subjectOcular administrationpt_PT
dc.subjectHET-CAMpt_PT
dc.titleEffect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospherespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage56pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume72pt_PT
person.familyNameLopes
person.familyNameSouto
person.givenNameCarla
person.givenNameEliana B.
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridM-4689-2016
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id8839435500
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublication.latestForDiscoveryb9f031fa-7f68-4196-b9c6-9f17cd542f12

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