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Influência dos antiangiogénicos na prática de Medicina Dentária: uma revisão sistemática
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Objetivo: Avaliar criticamente os estudos que abordam a terapêutica antiangiogénica de forma a orientar o Médico Dentista na decisão clínica. Pretendeu-se responder à questão: Qual a influência dos antiangiogénicos em tratamentos cirúrgicos em Medicina Dentária?
Métodos: Efetuou-se uma pesquisa bibliográfica nas bases de dados B-on, PubMed, SienceDirect, EBSCO Dentistry & Oral Sciences Source, SciELO, Cochrane Library, foi conduzida pelas guidelines do PRISMA. Os critérios de inclusão e exclusão foram identificados bem como o risco de viés foi obtido através da checklist da JBI Critical Appraisal Checklist for Case Reports.
Resultados: Incluíram-se 10 artigos após aplicação dos critérios de inclusão e exclusão, 2 destes apesar de serem elegíveis não apresentam resultados específicos . Nos artigos analisados as complicações apresentadas foram necrose óssea, hemorragia e alteração gengival, xerostomia, alveolite e osteomielite.
Conclusão: A terapêutica antiangiogénica tem impacto nos tratamentos dentários bem como na qualidade de vida dos doentes.
Objective: To critically evaluate the studies that address antiangiogenic therapy in order to guide the dentist in clinical decisions. We aimed to answer the question: What is the influence of antiangiogenic agents in surgical treatments in dentistry? Methods: A literature search in B-on, PubMed, SienceDirect, EBSCO Dentistry & Oral Sciences Source, SciELO, Cochrane Library databases was conducted using PRISMA guidelines. Inclusion and exclusion criteria were identified and the risk of bias was obtained using the JBI Critical Appraisal Checklist for Case Reports checklist. Results: Ten articles were included after application of the inclusion and exclusion criteria, 2 of which, despite being eligible, did not present specific results. In the analyzed articles, the complications presented were bone necrosis, hemorrhage and gingival alteration, xerostomia, alveolitis and osteomyelitis. Conclusion: Antiangiogenic therapy has an impact on dental treatments as well as on the quality of life of patients.
Objective: To critically evaluate the studies that address antiangiogenic therapy in order to guide the dentist in clinical decisions. We aimed to answer the question: What is the influence of antiangiogenic agents in surgical treatments in dentistry? Methods: A literature search in B-on, PubMed, SienceDirect, EBSCO Dentistry & Oral Sciences Source, SciELO, Cochrane Library databases was conducted using PRISMA guidelines. Inclusion and exclusion criteria were identified and the risk of bias was obtained using the JBI Critical Appraisal Checklist for Case Reports checklist. Results: Ten articles were included after application of the inclusion and exclusion criteria, 2 of which, despite being eligible, did not present specific results. In the analyzed articles, the complications presented were bone necrosis, hemorrhage and gingival alteration, xerostomia, alveolitis and osteomyelitis. Conclusion: Antiangiogenic therapy has an impact on dental treatments as well as on the quality of life of patients.
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Fármacos antiangiogénicos Tratamentos dentários Osso Efeitos adversos Antiangiogenic drugs Dental treatment Bone Adverse effects