Repository logo
 
Publication

Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases

2020-04Journal article Restricted access
Simple item page
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorAmaral, Maria Helena Amaral
dc.contributor.authorCosta, Paulo C.
dc.date.accessioned2020-09-22T09:01:55Z
dc.date.available2020-09-22T09:01:55Z
dc.date.issued2020-04
dc.date.updated2020-07-23T08:43:37Z
dc.description.abstractThe central nervous system (CNS) is vulnerable to pathologic processes that lead to the development of neurodegenerative disorders like Alzheimer’s, Parkinson’s and Huntington’s diseases, Multiple sclerosis or Amyotrophic lateral sclerosis. These are chronic and progressive pathologies characterized by the loss of neurons and the formation of misfolded proteins. Additionally, neurodegenerative diseases are accompanied by a structural and functional dysfunction of the blood-brain barrier (BBB). Although serving as a protection for CNS, the existence of physiological barriers, especially the BBB, limits the access of several therapeutic agents to the brain, constituting a major hindrance in neurotherapeutics advancement. In this regard, nanotechnology-based approaches have arisen as a promising strategy to not only improve drug targeting to the brain, but also to increase bioavailability. Lipid nanocarriers such as liposomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), microemulsions and nanoemulsions, have already proven their potential for enhancing brain transport, crossing more easily into the CNS and allowing the administration of medicines that could benefit the treatment of neurological pathologies. Given the socioeconomic impact of such conditions and the advent of nanotechnology that inevitably leads to more effective and superior therapeutics for their management, it is imperative to constantly update on the current knowledge of these topics. Herein, we provide insight on the BBB and the pathophysiology of the main neurodegenerative disorders. Moreover, this review seeks to highlight the several approaches that can be used to improve the delivery of therapeutic agents to the CNS, while also offering an extensive overview of the latest efforts regarding the use of lipid-based nanocarriers in the management of neurodegenerative diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1016/j.ejpb.2020.01.005pt_PT
dc.identifier.issn0939-6411
dc.identifier.slugcv-prod-1252754
dc.identifier.urihttp://hdl.handle.net/10284/8994
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectNeurodegenerative diseasespt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectBlood-brain barrier (BBB)pt_PT
dc.subjectBrain drug deliverypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectLipid nanocarrierspt_PT
dc.titleCurrent insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage217pt_PT
oaire.citation.startPage192pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume149pt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
European_Journal_of_Pharmaceutics_and_Biopharmaceutics_(2020),_doi_httpsdoi.org10.1016j.ejpb.2020.01.005.pdf
Size:
7.05 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.64 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS (DCF) - Artigos em Revistas Científicas Internacionais com Arbitragem Científica