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Contribution of catecholamine reactive intermediates and oxidative stress to the pathologic features of heart diseases

2011Journal article Restricted access
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dc.contributor.authorCosta, V.M.
dc.contributor.authorCarvalho, F.
dc.contributor.authorL. Bastos, M.
dc.contributor.authorA. Carvalho, R.
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorRemiao, F.
dc.date.accessioned2021-07-02T16:27:26Z
dc.date.available2021-07-02T16:27:26Z
dc.date.issued2011
dc.description.abstractPathologic heart conditions, particularly heart failure (HF) and ischemia-reperfusion (I/R) injury, are characterized by sustained elevation of plasma and interstitial catecholamine levels, as well as by the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Despite the continuous and extensive research on catecholamines since the early years of the XX(th) century, the mechanisms underlying catecholamine-induced cardiotoxicity are still not fully elucidated. The role of catecholamines in HF, stress cardiomyopathy, I/R injury, ageing, stress, and pheochromocytoma will be thoroughly discussed. Furthermore and although the noxious effects resulting from catecholamine excess have traditionally been linked to adrenoceptors, in fact, several evidences indicate that oxidative stress and the oxidation of catecholamines can have important roles in catecholamine-induced cardiotoxicity. Accordingly, the reactive intermediates formed during catecholamine oxidation have been associated with cardiac toxicity, both in in vitro and in vivo studies. An insight into the influence of ROS, RNS, and catecholamine oxidation products on several heart diseases and their clinical course will be provided. In addition, the source and type of oxidant species formed in some heart pathologies will be referred. In this review a special focus will be given to the research of cardiac pathologies where catecholamines and oxidative stress are involved. An integrated vision of these matters is required and will be provided along this review, namely how the concomitant surge of catecholamines and ROS occurs and how they can be interconnected. The concomitant presence of these factors can elicit peculiar and not fully characterized responses on the heart. We will approach the existing data with new perspectives as they can help explaining several controversial results regarding cardiovascular diseases and the redox ability of catecholamines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/092986711795656081pt_PT
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/10284/10042
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.relationPPCDT/SAU-OBS/55849/2004pt_PT
dc.subjectCatecholaminespt_PT
dc.subjectOxidative stresspt_PT
dc.subjectCardiovascular toxicitypt_PT
dc.titleContribution of catecholamine reactive intermediates and oxidative stress to the pathologic features of heart diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FSAU-OBS%2F55849%2F2004/PT
oaire.citation.endPage2314pt_PT
oaire.citation.issue15pt_PT
oaire.citation.startPage2272pt_PT
oaire.citation.titleCurrent Medicinal Chemistrypt_PT
oaire.citation.volume18pt_PT
oaire.fundingStreamPOCI
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6
relation.isProjectOfPublication4ca44686-b588-45ee-9c0d-af8cf4bdbd30
relation.isProjectOfPublication.latestForDiscovery4ca44686-b588-45ee-9c0d-af8cf4bdbd30

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