Repository logo
 
Publication

Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): a current overview of active targeting in brain diseases

2023Journal article Restricted access
Simple item page
dc.contributor.authorTeixeira, Maria Inês
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorAmaral, Maria Helena
dc.contributor.authorCosta, Paulo C.
dc.date.accessioned2024-01-30T14:44:02Z
dc.date.available2024-01-30T14:44:02Z
dc.date.issued2023
dc.description.abstractThe blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain, complicating the treatment of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), glioma, etc. To overcome this limitation and improve drug delivery to the central nervous system (CNS), the potential of nanocarriers, including lipid-based nanosystems, has been explored. Through active targeting, the surface of the nanocarriers can be modified with ligands that interact with the BBB, enhancing their uptake and penetration across the brain endothelium by different physiological mechanisms, such as receptor- or transporter-mediated transcytosis. This review seeks to provide an overview of active targeting in brain delivery, while highlighting the potential of functionalized lipid nanocarriers to treat brain diseases. Therefore, in the first sections, we discuss the importance of active targeting in CNS drug delivery, present the different ligands commonly used for functionalization, as well as summarize the state of the art of the most recent and relevant studies of surface-modified lipid nanosystems developed for neurological disorders. Lastly, challenges hindering clinical translation are discussed, and critical insights and future perspectives outlined. Although some limitations have been identified, it is expected that in the upcoming years these nanosystems will be an established approach.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTeixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2023). Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): a current overview of active targeting in brain diseases. Colloids and Surfaces B: Biointerfaces, 112999. https://doi.org/10.1016/j.colsurfb.2022.112999pt_PT
dc.identifier.doi10.1016/j.colsurfb.2022.112999pt_PT
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/10284/12626
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectBlood-brain barrier (BBB)pt_PT
dc.subjectCentral nervous system (CNS)pt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectLipid nanoparticlespt_PT
dc.subjectTargetingpt_PT
dc.subjectSurface modificationpt_PT
dc.titleSurface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): a current overview of active targeting in brain diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage112999pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume221pt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Teixeira et al. Colloids and Surfaces B_ Biointerfaces _ 2023.pdf
Size:
10.36 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - Artigos em Revistas Científicas Internacionais com Arbitragem Científica