Repository logo
 
Publication

Delivery systems for biopharmaceuticals. Part I: nanoparticles and microparticles

2015Journal article Restricted access
Simple item page
dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorLobo, J.M. Sousa
dc.contributor.authorAmaral, M.H.
dc.date.accessioned2020-09-29T15:44:17Z
dc.date.available2020-09-29T15:44:17Z
dc.date.issued2015
dc.date.updated2020-07-24T15:27:38Z
dc.description.abstractPharmaceutical biotechnology has been showing therapeutic success never achieved with conventional drug molecules. Therefore, biopharmaceutical products are currently well-established in clinic and the development of new ones is expected. These products comprise mainly therapeutic proteins, although nucleic acids and cells are also included. However, according to their sensitive molecular structures, the efficient delivery of biopharmaceuticals is challenging. Several delivery systems (e.g. microparticles and nanoparticles) composed of different materials (e.g. polymers and lipids) have been explored and demonstrated excellent outcomes, such as: high cellular transfection efficiency for nucleic acids, cell targeting, increased proteins and peptides bioavailability, improved immune response in vaccination, and viability maintenance of microencapsulated cells. Nonetheless, important issues need to be addressed before they reach clinics. For example, more in vivo studies in animals, accessing the toxicity potential and predicting in vivo failure of these delivery systems are required. This is the Part I of two review articles, which presents the state of the art of delivery systems for biopharmaceuticals. Part I deals with polymeric and lipid microparticles and nanoparticles.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1389201016666150731112532pt_PT
dc.identifier.issn1389-2010
dc.identifier.slugcv-prod-337020
dc.identifier.urihttp://hdl.handle.net/10284/9012
dc.language.isoengpt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectBiopharmaceuticalspt_PT
dc.subjectProteinspt_PT
dc.subjectPeptidespt_PT
dc.subjectNucleic acidspt_PT
dc.subjectCellspt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.subjectLipid nanoparticlespt_PT
dc.subjectMicroparticlespt_PT
dc.titleDelivery systems for biopharmaceuticals. Part I: nanoparticles and microparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage954pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage940pt_PT
oaire.citation.titleCurrent Pharmaceutical Biotechnologypt_PT
oaire.citation.volume16pt_PT
person.familyNameSilva
person.familyNameLopes
person.givenNameAna Catarina
person.givenNameCarla
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-6923-0232
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridF-1875-2017
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id57028697500
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Current_Pharmaceutical_Biotechnology___Part_I___2015.pdf
Size:
529.48 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.64 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS (DCF) - Artigos em Revistas Científicas Internacionais com Arbitragem Científica