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Synergistic antimicrobial activity of silver nanoparticles with an emergent class of azoimidazoles

2023-03-13Artigo científico Acesso aberto
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dc.contributor.authorRibeiro, Ana Isabel
dc.contributor.authorDantas, Daniela
dc.contributor.authorCarvalho, Luís Filipe
dc.contributor.authorPadrão, Jorge
dc.contributor.authorSilva, Renata
dc.contributor.authorRemião, Fernando
dc.contributor.authorPinto, Eugénia
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorDias, Alice
dc.contributor.authorZille, Andrea
dc.date.accessioned2026-04-20T09:58:45Z
dc.date.available2026-04-20T09:58:45Z
dc.date.issued2023-03-13
dc.description.abstractThe combination of two or more agents capable of acting in synergy has been reported as a valuable tool to fight against pathogens. Silver nanoparticles (AgNPs) present a strong antimicrobial action, although their cytotoxicity for healthy cells at active concentrations is a major concern. Azoimidazole moieties exhibit interesting bioactivities, including antimicrobial activity. In this work, a class of recently described azoimidazoles with strong antifungal activity was conjugated with citrate or polyvinylpyrrolidone-stabilized AgNPs. Proton nuclear magnetic resonance was used to confirm the purity of the compounds before further tests and atomic absorption spectroscopy to verify the concentration of silver in the prepared dispersions. Other analytical techniques elucidate the morphology and stability of AgNPs and corresponding conjugates, namely ultraviolet-visible spectrophotometry, scanning transmission electron microscopy and dynamic light scattering analysis. The synergistic antimicrobial activity of the conjugates was assessed through a checkerboard assay against yeasts ( and ) and bacteria ( and ). The conjugates showed improved antimicrobial activity against all microorganisms, in particular towards bacteria, with concentrations below their individual minimal inhibitory concentration (MIC). Furthermore, some combinations were found to be non-cytotoxic towards human HaCaT cells.eng
dc.identifier.citationRibeiro, A. I., Dantas, D., Carvalho, L. F., Padrão, J., Silva, R., Remião, F., Pinto, E., Cerqueira, F., Dias, A. M., & Zille, A. (2024). Synergistic anti-bacterial activity of imidazole-based azo dyes with polyvinylpyrrolidone-coated silver nanoparticles. Coloration Technology, 140(5), 719–727. https://doi.org/10.1111/cote.12732
dc.identifier.doi10.1111/cote.12732
dc.identifier.other36986787
dc.identifier.urihttp://hdl.handle.net/10284/15355
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/cote.12732
dc.rights.uriN/A
dc.subjectAntibacterial
dc.subjectAntifungal
dc.subjectSilver nanoparticles
dc.subjectStabilizing agents
dc.subjectSynergism
dc.titleSynergistic antimicrobial activity of silver nanoparticles with an emergent class of azoimidazoleseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage727
oaire.citation.issue5
oaire.citation.startPage719
oaire.citation.titleColoration Technology
oaire.citation.volume140
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCerqueira
person.familyNameDias
person.familyNameZille
person.givenNameFátima
person.givenNameAlice
person.givenNameAndrea
person.identifier812695
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0002-5111-0774
person.identifier.orcid0000-0001-5299-4164
person.identifier.ridM-7557-2013
person.identifier.scopus-author-id6603346911
relation.isAuthorOfPublicationaee0f72a-a52e-45af-bbb1-cc5cfda78815
relation.isAuthorOfPublication1700ad8c-b660-48e5-abca-e25cf29e4239
relation.isAuthorOfPublication733be83e-9e50-4c2f-9bd4-035f8645d48b
relation.isAuthorOfPublication.latestForDiscoveryaee0f72a-a52e-45af-bbb1-cc5cfda78815

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