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Application of the Quality-by-Design (QbD) approach to improve the nose-to-brain delivery of diazepam-loaded Nanostructured Lipid Carriers (NLCs)

2021Journal article Restricted access
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dc.contributor.authorCosta, Cláudia Pina
dc.contributor.authorCunha, Sara
dc.contributor.authorPeixoto, Andreia F.
dc.contributor.authorMoreira, João Nuno
dc.contributor.authorLobo, José Manuel Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-28T15:40:45Z
dc.date.available2021-04-28T15:40:45Z
dc.date.issued2021
dc.description.abstractThe intranasal administration of nanostructured lipid carriers (NLCs) has been suggested as a promising strategy to improve the fast treatment of epilepsy. This route allows for drug passage directly from the nose to the brain, avoiding the need of bypassing the blood–brain barrier. In addition, the quality-by-design (QbD) approach is a useful tool for the optimization of manufacturing variables, resulting in effective and safe pharmaceutical formulations. The aim of this work was to use the QbD approach to optimize a NLCs formulation for the nose-to-brain delivery of diazepam. The studies began with the screening of excipients and the assessment of the lipid-drug compatibility. The central composite design was used to evaluate the effects of critical material attributes (CMAs) (ratio of solid and liquid lipids and the amount of drug and emulsifiers) on the CQAs of the diazepam-loaded NLCs formulation (particle size, polydispersity index (PDI), zeta potential (ZP) and encapsulation efficiency (EE)). The results showed that the most adequate ratios of lipids and emulsifiers were 6.65:2.85 and 4.2:0.3 (%, w/w), with values of 84.92 nm, 0.18, −18.20 mV and 95.48% for particle size, PDI, ZP and EE, respectively. This formulation was selected for further studies related to the optimization of critical process parameters (CPPs).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/IECP2020-08658pt_PT
dc.identifier.issn2504-3900
dc.identifier.urihttp://hdl.handle.net/10284/9820
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectEpilepsypt_PT
dc.subjectNose-to-brain deliverypt_PT
dc.subjectIntranasal deliverypt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectQuality-by-designpt_PT
dc.titleApplication of the Quality-by-Design (QbD) approach to improve the nose-to-brain delivery of diazepam-loaded Nanostructured Lipid Carriers (NLCs)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage40pt_PT
oaire.citation.titleProceedingspt_PT
oaire.citation.volume78pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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