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O uso de bifosfonatos como coadjuvante na terapia periodontal: uma revisão narrativa
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Advisor(s)
Abstract(s)
Introdução: A periodontite é uma doença inflamatória de etiologia multifatorial, cuja terapêutica padrão ouro é raspagem e alisamento radicular, com o objetivo de reduzir a microbiota e permitir que a inflamação cesse. Porém, por limitações anatómicas ou alterações sistémicas, a severidade do processo justifica a associação com fármacos para obter melhores resultados. Ao buscar opções medicamentosas para estas situações clínicas, os bifosfonatos, apresentam-se como candidatos.
Objetivo: Demonstrar as evidências atuais para o uso de bifosfonatos, como fármaco adjunto para tratamento de periodontite.
Materiais e métodos: Foi realizada revisão narrativa, considerando os principais estudos acerca do uso dos bisfosfonatos como adjunto a terapia periodontal nos últimos 5 anos.
Resultados e conclusões: Como achados principais, pode-se destacar que, quando usado de forma tópica, os parâmetros clínicos são superiores, principalmente em lesões de furca e defeitos infra ósseos, porém os estudos ainda são insuficientes para definir o uso como adjunto a terapia padrão.
Introduction: Periodontitis is an inflammatory disease of multifactorial etiology, whose gold standard therapy is scaling and root planning, with the aim of reducing the microbiota and allowing inflammation to cease. However, due to anatomical limitations or systemic changes, the severity of the process justifies the association with drugs to obtain better results. When looking for drug options for these clinical situations, bisphosphonates present themselves as candidates. Objective: To demonstrate the current evidence for the use of bisphosphonates as an adjunct drug for the treatment of periodontitis. Materials and methods: A narrative review was carried out, considering the main studies on the use of bisphosphonates as an adjunct to periodontal therapy in the last 5 years. Results and conclusions: As main findings, it can be highlighted that, when used topically, the clinical parameters are superior, especially in furcation lesions and infrabone defects, but the studies are still insufficient to define the use as an adjunct to standard therapy.
Introduction: Periodontitis is an inflammatory disease of multifactorial etiology, whose gold standard therapy is scaling and root planning, with the aim of reducing the microbiota and allowing inflammation to cease. However, due to anatomical limitations or systemic changes, the severity of the process justifies the association with drugs to obtain better results. When looking for drug options for these clinical situations, bisphosphonates present themselves as candidates. Objective: To demonstrate the current evidence for the use of bisphosphonates as an adjunct drug for the treatment of periodontitis. Materials and methods: A narrative review was carried out, considering the main studies on the use of bisphosphonates as an adjunct to periodontal therapy in the last 5 years. Results and conclusions: As main findings, it can be highlighted that, when used topically, the clinical parameters are superior, especially in furcation lesions and infrabone defects, but the studies are still insufficient to define the use as an adjunct to standard therapy.
Description
Keywords
Periodontite Bifosfonato Alendronato Doença periodontal Perda óssea Periodontitis Biphosphonate Alendronate Periodontal disease Bone loss