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Antispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal)

2013Journal article Open access
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dc.contributor.authorMoutinho, Carla
dc.contributor.authorMatos, Carla
dc.contributor.authorJosé Manuel, Neves
dc.contributor.authorTeixeira, Dora Martins
dc.contributor.authorCunha, Sílvia
dc.contributor.authorGomes, Lígia Rebelo
dc.date.accessioned2019-12-27T09:20:36Z
dc.date.available2019-12-27T09:20:36Z
dc.date.issued2013
dc.description.abstractThe wild mint Mentha x piperita (Mentha rotundifolia Huds.), has been used by the local people in a northern region of Portugal to prepare infusions for treating digestive pain and spasms, as an appetite stimulant and for treating headache and migraine. This suggests that these aqueous extracts have analgesic; antispasmodic and stomachic properties. In the present study the antioxidant potential of aqueous extracts of Mentha x piperita is investigated since natural antioxidants can scavenge the reactive oxygen species, ROS, and thus might attenuate inflammation pathways. The antispasmodic activity was also checked. The antioxidant potential of the extract was evaluated by the DPPH• method, by the quantification of the total phenolic compounds and by characterization of the main phenolic compounds. The antispasmodic effects were investigated by performing pharmacological assays using the distal ileum of guinea pigs. The aqueous extract exhibits antioxidant properties that may be due to its phenolic content. The main phenolic compounds were quinic, caffeic, rosmarinic and chlorogenic acids. The antispasmodic affects are observed after electrical stimulation of segments of distal ileum of guinea pigs and may be attributed, at least, to a alfa-1 blockage.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoutinho, C.; Matos, Carla M.; Neves, J. M.; Teixeira, Dora Martins; Cunha, Sílvia; Gomes, Lígia Rebelo, Antispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal). International Journal of Indigenous Medicinal Plants, 29(1), 1167-1174, 2013pt_PT
dc.identifier.issn2051-4263
dc.identifier.issn2051-4263
dc.identifier.urihttp://hdl.handle.net/10284/8343
dc.language.isospapt_PT
dc.peerreviewedyespt_PT
dc.publisherRecent Science Publisherspt_PT
dc.subjectMentha x piperitapt_PT
dc.subjectPhenolic contentpt_PT
dc.subjectAntispasmodic activitypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.titleAntispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1174pt_PT
oaire.citation.startPage1167pt_PT
oaire.citation.titleInternational Journal of Indigenous Medicinal Plantspt_PT
oaire.citation.volume29 (1)pt_PT
person.familyNameMoutinho
person.familyNameMatos
person.familyNameMaria da Silva Rebelo Gomes
person.givenNameCarla
person.givenNameCarla
person.givenNameLígia
person.identifier1536969
person.identifier.ciencia-idB61F-F356-80C6
person.identifier.ciencia-id721C-DA34-256E
person.identifier.ciencia-idA41A-22BE-18F0
person.identifier.orcid0000-0003-1310-4696
person.identifier.orcid0000-0003-0617-3538
person.identifier.orcid0000-0002-3496-6052
person.identifier.ridM-7142-2013
person.identifier.scopus-author-id16064733800
person.identifier.scopus-author-id7004493818
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcff7638e-1f33-4384-aa73-d3acc5cca5f8
relation.isAuthorOfPublicationd4b6d3e1-6d29-4fb4-97c7-abb2cf4c83b4
relation.isAuthorOfPublication66614656-b892-46ad-93f3-7586580fd733
relation.isAuthorOfPublication.latestForDiscovery66614656-b892-46ad-93f3-7586580fd733

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