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Inhibitory effect of 5-aminoimidazole-4-carbohydrazonamides derivatives against Candida spp. biofilm on nanohydroxyapatite substrate

2019Journal article Embargoed access
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dc.contributor.authorGabriel, C.
dc.contributor.authorGrenho, L.
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorMedeiros, R.
dc.contributor.authorDias, A. M.
dc.contributor.authorRibeiro, A. I.
dc.contributor.authorProença, M. F.
dc.contributor.authorFernandes, M. H.
dc.contributor.authorSousa, J. C.
dc.contributor.authorMonteiro, F. J.
dc.contributor.authorFerraz, M. P.
dc.date.accessioned2019-11-18T08:22:59Z
dc.date.embargo2029-01-01
dc.date.issued2019
dc.description.abstractCandida can adhere and form biofilm on biomaterials commonly used in medical devices which is a key attribute that enhances its ability to cause infections in humans. Furthermore, biomaterial-related infections represent a major therapeutic challenge since Candida biofilms are implicated in antifungal therapies failure. The goals of the present work were to investigate the effect of three 5-aminoimidazole-4-carbohydrazonamides, namely (Z)-5-amino-1-methyl-N'-aryl-1H-imidazole-4-carbohydrazonamides [aryl = phenyl (1a), 4-fluorophenyl (1b), 3-fluorophenyl (1c)], on Candida albicans and Candida krusei biofilm on nanohydroxyapatite substrate, a well-known bioactive ceramic material. To address these goals, both quantitative methods (by cultivable cell numbers) and qualitative evaluation (by scanning electron microscopy) were used. Compounds cytocompatibility towards osteoblast-like cells was also evaluated after 24 h of exposure, through resazurin assay. The three tested compounds displayed a strong inhibitory effect on biofilm development of both Candida species as potent in vitro activity against C. albicans sessile cells. Regarding cytocompatibility, a concentration-dependent effect was observed. Together, these findings indicated that the potent activity of imidazole derivatives on Candida spp. biofilms on nanohydroxyapatite substrate, in particular compound 1c, is worth further investigating.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11046-019-00400-4pt_PT
dc.identifier.issn0301-486X
dc.identifier.issn1573-0832
dc.identifier.urihttp://hdl.handle.net/10284/8228
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11046-019-00400-4pt_PT
dc.subjectBiomaterialspt_PT
dc.subjectBiofilmspt_PT
dc.titleInhibitory effect of 5-aminoimidazole-4-carbohydrazonamides derivatives against Candida spp. biofilm on nanohydroxyapatite substratept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMycopathologiapt_PT
person.familyNameGrenho
person.familyNameCerqueira
person.familyNameMedeiros
person.familyNameFerraz
person.givenNameLiliana
person.givenNameFátima
person.givenNameRui
person.givenNameMaria Pia
person.identifierR-000-M1P
person.identifier812695
person.identifier37604
person.identifier.ciencia-idB41C-D747-BDBF
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.ciencia-idC51F-5DBE-9C51
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person.identifier.orcid0000-0001-9476-2839
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0003-3010-8373
person.identifier.orcid0000-0002-0274-106X
person.identifier.ridI-4540-2015
person.identifier.ridM-7557-2013
person.identifier.ridC-7938-2009
person.identifier.ridM-6316-2013
person.identifier.scopus-author-id55159751400
person.identifier.scopus-author-id6603346911
person.identifier.scopus-author-id7006241641
person.identifier.scopus-author-id7102012951
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb26a2a2c-0484-4214-97b3-b7ea69b58419
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
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