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Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions

2021Journal article Restricted access
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dc.contributor.authorSilva-Neves, Vasco
dc.contributor.authorHugo, Vitor
dc.contributor.authorAlves, Paulo
dc.contributor.authorAmado, João Costa
dc.contributor.authorPais-Vieira, Carla
dc.contributor.authorSousa, Fátima
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorPinto, Eugénia
dc.contributor.authorPais-Vieira, Miguel
dc.date.accessioned2021-07-13T11:58:56Z
dc.date.available2021-07-13T11:58:56Z
dc.date.issued2021
dc.description.abstractOnychomycosis or tinea unguium (EE12.1) and Onychomycosis due to non-dermatophyte moulds (1F2D.5) (OM) is a fungal infection of the nail plates with a high prevalence that often afects vulnerable people with co-existing health problems. Gold standard pharmacological treatments for onychomycosis have been associated with low success rates and increasing antifungal resistance, suggesting that treatment outcome is dependent on multiple variables. Here, the prevalence of OM and quality of life were characterized in two vulnerable populations—Hospital patients and Homeless people. Comparing both groups, the most prevalent fungal species were identifed in Hospital patients. Then, the in vitro fungicidal properties of the antiseptics povidone-iodine, polyhexamethylene biguanide-betaine, octenidine dihydrochloride, and a super-oxidized solution against two ATCC strains (Candida albicans and Aspergillus niger) and three clinical fungal isolates from Hospital patients (Candida parapsilosis, Trichophyton interdigitale, and Trichophyton rubrum) were tested. OM prevalence was high in both patient groups studied, who also reported a reduction in quality of life and concerns about the state of their feet. In addition, Hospital patients had a nonnegligent therapeutic regimen management style. Antiseptics tested in vitro revealed antifungal properties. As antiseptics are low-cost and easy to apply and have few iatrogenic efects, the demonstration of fungicidal properties of these solutions suggests that they may constitute potential supportive therapeutics for OM.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41598-021-92111-4pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10284/10074
dc.language.isoengpt_PT
dc.publisherSpringer Naturept_PT
dc.titleQuality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage12789pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume11pt_PT
person.familyNameCerqueira
person.givenNameFátima
person.identifier812695
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.orcid0000-0003-4513-4654
person.identifier.ridM-7557-2013
person.identifier.scopus-author-id6603346911
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
relation.isAuthorOfPublication.latestForDiscovery2705e35c-97f6-4de2-bbf1-d680342760e9

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