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Publication
Teste de suscetibilidade genética para a periodontite
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_17998 | 218.5 KB | Adobe PDF |
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Advisor(s)
Abstract(s)
Os testes de suscetibilidade genética para a periodontite foram desenvolvidos e comercializados sob a premissa da deteção precoce da doença num estágio de desenvolvimento de melhor prognóstico e a promoção do avanço no bem-estar odontológico do paciente. Estes testes detetam a presença específica de polimorfismos do gene IL-1 considerados responsáveis pela sobreprodução inflamatória associados ao risco aumentado e à alta prevalência da severidade da periodontite.
O desenvolvimento de estudos com o intuito de verificar a eficácia destes testes, o seu comprometimento genético a diferentes etnias e os fatores condicionantes associados, não permitem tirar conclusões acerca da sua utilidade clínica, pois os resultados encontrados e as controvérsias ao tema são notórios.
A necessidade de estudos adicionais e novos avanços científicos na área da genética são fundamentais para a criação de um teste com eficácia no diagnóstico da doença e, consequentemente ao desenvolvimento de uma atuação clínica preventiva e personalizada.
A genetic susceptibility test to periodontitis was developed and commercialized with the aim to detect disease at an earlier and more treatable stage, and to advance patient’s odontological wellness. That tests detect the specific presence of IL-1 gene variations, responsible to overproduce IL-1, leading to a chronic inflammatory disease such as periodontitis. The development of several studies, with aim to verify the efficacy of this type of tests and be validated in multiple ethnic populations don’t be conclusive about is clinical utility. The scientific findings have presented some controversies. It suggests that further scientific studies and more complete genetics’ assessment may be useful to create a diagnostic test and in identifying patients with individual susceptibility profile to the disease, for an effective and preventive periondontal therapy.
A genetic susceptibility test to periodontitis was developed and commercialized with the aim to detect disease at an earlier and more treatable stage, and to advance patient’s odontological wellness. That tests detect the specific presence of IL-1 gene variations, responsible to overproduce IL-1, leading to a chronic inflammatory disease such as periodontitis. The development of several studies, with aim to verify the efficacy of this type of tests and be validated in multiple ethnic populations don’t be conclusive about is clinical utility. The scientific findings have presented some controversies. It suggests that further scientific studies and more complete genetics’ assessment may be useful to create a diagnostic test and in identifying patients with individual susceptibility profile to the disease, for an effective and preventive periondontal therapy.
Description
Keywords
Periodontite Polimorfismos IL-1 Teste de suscetibilidade genética Periodontitis Il-1 polymorphisms Genetic susceptibility test