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Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo

2004Journal article Restricted access
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dc.contributor.authorValentão, Patrícia
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorCarvalho, Félix
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorPires das Neves, Ricardo
dc.contributor.authorPereira, M. Lourdes
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorSeabra, Rosa M.
dc.contributor.authorBastos, M. Lourdes
dc.date.accessioned2021-07-01T15:45:44Z
dc.date.available2021-07-01T15:45:44Z
dc.date.issued2004
dc.description.abstractIncreasing evidence regarding free radical generating agents indicates that the sustained production of high levels of reactive oxygen species (ROS) can cause hepatotoxicity. Being a short chain analog of lipid peroxide, tert-butyl hydroperoxide (t-BHP) is metabolized into free radical intermediates by cytochrome P450 in hepatocytes, which initiate lipid peroxidation, glutathione depletion and cell damage. The aim of the present study was to evaluate the putative protective effect of Hypericum androsaemum lyophilised infusion against t-BHP-induced mice hepatotoxicity in vivo, which has already been shown to be antioxidant in vitro. However, the results showed that the oral pretreatment with Hypericum androsaemum infusion (4, 20 and 100 mg/kg) for 4 days before a single intraperitoneal dose of t-BHP (1.8 mmol/kg) potentiated the t-BHP-induced hepatotoxicity. In fact, it was observed a potentiation in the depletion of total glutathione and reduced glutathione (GSH) contents and increase in oxidised glutathione (GSSG) level. Also the histopathological evaluation of the mice livers revealed that the infusion raised the incidence of liver lesions induced by t-BHP. These data do not corroborate any effect of Hypericum androsaemum infusion as hepatoprotector, but rather as a potentiator of hepatotoxicity in the present experimental conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jep.2004.06.012pt_PT
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10284/10003
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationThe authors are grateful to the Agência Inovação and PRAXIS XXI (PLANTAMEDI project) for financial support of this work, and to Dr. Laura Pereira for technical support in the measurement of plasma parameters. P. Valentão is indebted to Fundação para a Ciência e Tecnologia for a Ph.D. grant (PRAXIS XXI/BD/15740/98).pt_PT
dc.subjectHypericum androsaemumpt_PT
dc.subjectTert-Butyl hydroperoxidept_PT
dc.subjectHepatotoxicitypt_PT
dc.titleHypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage351pt_PT
oaire.citation.issue2-3pt_PT
oaire.citation.startPage345pt_PT
oaire.citation.titleJournal of Ethnopharmacologypt_PT
oaire.citation.volume94pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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