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Associação entre periodontite e COVID-19: revisão narrativa
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| 37917 | 390.99 KB | Adobe PDF |
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Abstract(s)
O coronavírus 2019 (COVID-19) tornou-se uma nova preocupação mundial, resultando na morte de milhões de pessoas, embora tenho uma taxa de mortalidade de apenas 2,1 %. É uma infeção viral causada pelo coronavírus da síndrome respiratória aguda grave (SARS-CoV-2) que afeta clinicamente vários órgãos do corpo humano. Estudos recentes reportam que pacientes da COVID-19 apresentam manifestações orais com aspetos clínicos múltiplos. As doenças periodontais compreendem um grupo de doenças que implica o hospedeiro e aspectos inflamatórios sistémicos que afetam os tecidos periodontais. Os níveis elevados de mediadores pro inflamatórios em doentes com COVID-19 e doenças infeciosas orais podem alterar a homeotase dos tecidos e retardar a resolução da doença. Os principais sinais e sintomas da COVID-19 na cavidade oral, a sua possível associação com doenças periodontais e mecanismos plausíveis subjacentes de hiperinflamação refletem uma interação entre COVID-19 e as doenças. O tratamento periodontal de rotina pode ajudar a reduzir os sintomas da COVID-19.
O objetivo desta revisão é estudar a possível associação entre a periodontite e a COVID-19 através de sinais e sintomas na cavidade bucal e abordar possíveis tratamentos a serem realizados no momento da visita dentária para estabilizar a condição oral. Para realizar este estudo, forem usadas diferentes plataformas de pesquisa na Internet, tais como B-On, Google Scholar, Pub Med ou Scielo encontrados um total de 942 resultados bibliográficos de referência. Utilizados 86 dos artigos mais relevantes para analisar o tema a partir de diferentes ângulos.
Por ser a COVID-19 uma doença recente, são necessárias futuras investigações, entretanto as evidências permitem concluir que a periodontite, pode favorecer a evolução para sintomas respiratórios graves.
The 2019 coronavirus (COVID-19) has become a new worldwide concern, resulting in the deaths of millions of people, although it has a fatality rate of only 2.1%. It is a viral infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) that clinically affects various organs of the human body. Recent studies have reported that COVID-19 patients have oral manifestations with multiple clinical aspects. Periodontal disease comprises a group of diseases involving both host and systemic inflammatory aspects that affect periodontal tissues. Elevated levels of pro-inflammatory mediators in patients with COVID-19 and oral infectious diseases may alter tissue homeostasis and delay disease resolution. The main signs and symptoms of COVID-19 in the oral cavity, its possible association with periodontal diseases and plausible underlying mechanisms of hyperinflammation reflect an interaction between COVID-19 and oral diseases. Routine periodontal treatment can help reduce the symptoms of COVID-19. The aim of this review is to investigate the possible relationship between periodontal disease and COVID-19 through signs and symptoms in the oral cavity and to discuss possible treatments to be performed at the time of the dental visit to improve the dental condition. To carry out this study, we used different Internet search platforms, such as B-On, Google Scholar, Pub Med or Scielo, with a total of 942 bibliographic reference results. We used 86 of the most relevant articles to analyze the topic from different angles. Because COVID-19 is a recent disease, further investigations are needed, however the evidence allows us to conclude that periodontitis may favor the evolution to severe respiratory symptoms.
The 2019 coronavirus (COVID-19) has become a new worldwide concern, resulting in the deaths of millions of people, although it has a fatality rate of only 2.1%. It is a viral infection caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) that clinically affects various organs of the human body. Recent studies have reported that COVID-19 patients have oral manifestations with multiple clinical aspects. Periodontal disease comprises a group of diseases involving both host and systemic inflammatory aspects that affect periodontal tissues. Elevated levels of pro-inflammatory mediators in patients with COVID-19 and oral infectious diseases may alter tissue homeostasis and delay disease resolution. The main signs and symptoms of COVID-19 in the oral cavity, its possible association with periodontal diseases and plausible underlying mechanisms of hyperinflammation reflect an interaction between COVID-19 and oral diseases. Routine periodontal treatment can help reduce the symptoms of COVID-19. The aim of this review is to investigate the possible relationship between periodontal disease and COVID-19 through signs and symptoms in the oral cavity and to discuss possible treatments to be performed at the time of the dental visit to improve the dental condition. To carry out this study, we used different Internet search platforms, such as B-On, Google Scholar, Pub Med or Scielo, with a total of 942 bibliographic reference results. We used 86 of the most relevant articles to analyze the topic from different angles. Because COVID-19 is a recent disease, further investigations are needed, however the evidence allows us to conclude that periodontitis may favor the evolution to severe respiratory symptoms.
Description
Keywords
COVID-19 SARS-CoV-2 Periodontite Recetores ACE2 Periodontal disease Periodontitis ACE2 receptors