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Evaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: in vitro and human in vivo studies

2019Journal article Restricted access
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dc.contributor.authorVaz, S.
dc.contributor.authorSilva, R.
dc.contributor.authorAmaral, M.H.
dc.contributor.authorMartins, E.
dc.contributor.authorLobo, J.M. Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-28T08:39:43Z
dc.date.available2021-04-28T08:39:43Z
dc.date.issued2019
dc.description.abstractLipid-based nanosystems, such as nanostructured lipid carriers (NLC) and nanoemulsions (NE) have been described as promising alternatives to conventional formulations for increase skin hydration. Besides, these systems have been used as efficient vehicles for lipophilic molecules that improve skin properties (e.g. vitamin E). In this study, we performed comparative investigations between hydrogels formulations containing vitamin E-loaded NLC (HG-NLCVE) and vitamin E-loaded nanoemulsion (HG-NEVE). The experiments started with particle size measurements, which showed no significant differences between nanoparticles/nanodroplets sizes after incorporation in the hydrogel net (386 nm vs. 397 nm for HG-NLCVE and 402 nm vs. 514 nm for HG-NEVE). Afterwards, in vitro biocompatibility studies in human keratinocytes were carried out, being observed that the lipid-based nanosystems were more cytotoxic for the cells before incorporation in the hydrogel. Finally, the formulations hydration potential and sensory attributes for skin application were evaluated by in vitro occlusion tests and in vivo human experiments. The results showed that the HG-NLCVE exhibited the best occlusive properties, whereas the HG-NEVE performed a faster skin hydration effect. Furthermore, the latter was selected as the most attractive for skin application, although the HG-NLCVE was described as more suitable to obtain a long-lasting effect. This study demonstrated the in vitro and in vivo safety and hydration potential of hydrogels containing vitamin E-loaded lipid-based nanosystems. These results establish a basis to assess the cutaneous use of these systems, despite more in vivo experiments, for longer periods and in more volunteers, are required before commercialization.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.colsurfb.2019.03.036pt_PT
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/10284/9809
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectLipid-based nanosystemspt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectNanoemulsionspt_PT
dc.subjectVitamin Ept_PT
dc.subjectCutaneous applicationpt_PT
dc.subjectHydrogelpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectSkin hydrationpt_PT
dc.titleEvaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: in vitro and human in vivo studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage249pt_PT
oaire.citation.startPage242pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume179pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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