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Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: a comparative study with green tea (Camellia sinensis)

2009Journal article Restricted access
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dc.contributor.authorCosta, Rossana M.
dc.contributor.authorMagalhães, Ana S.
dc.contributor.authorPereira, José A.
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorValentão, Patrícia
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorSilva, Branca M.
dc.date.accessioned2021-07-02T14:02:58Z
dc.date.available2021-07-02T14:02:58Z
dc.date.issued2009
dc.description.abstractThis study aimed to determine the phenolic profile and to investigate the antioxidant potential of quince (Cydonia oblonga) leaf, comparing it with green tea (Camellia sinensis). For these purposes, methanolic extracts were prepared and phenolics content of quince leaf was determined by HPLC/UV. The antioxidant properties were assessed by Folin-Ciocalteu reducing capacity assay and by the ability to quench the stable free radical 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and to inhibit the 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative hemolysis of human erythrocytes.5-O-Caffeoylquinic acid was found to be the major phenolic compound in quince leaf extract. Quince leaf exhibited a significantly higher reducing power than green tea (mean value of 227.8 +/- 34.9 and 112.5 +/- 1.5 g/kg dry leaf, respectively). Quince leaf extracts showed similar DPPH radical-scavenging activities (EC50 mean value of 21.6 +/- 3.5 microg/ml) but significantly lower than that presented by green tea extract (EC50 mean value of 12.7 +/- 0.1 microg/ml). Under the oxidative action of AAPH, quince leaf methanolic extract significantly protected the erythrocyte membrane from hemolysis in a similar manner to that found for green tea (IC50 mean value of 30.7 +/- 6.7 and 24.3 +/- 9.6 microg/ml, respectively, P > 0.05). These results point that quince leaf may have application as preventive or therapeutic agent in diseases in which free radicals are involved.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.fct.2009.01.019pt_PT
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10284/10031
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectCydonia oblongapt_PT
dc.subjectQuince leafpt_PT
dc.subjectHemolysispt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectCamellia sinensispt_PT
dc.titleEvaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: a comparative study with green tea (Camellia sinensis)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage865pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage860pt_PT
oaire.citation.titleFood and Chemical Toxicologypt_PT
oaire.citation.volume47pt_PT
person.familyNameCarvalho
person.familyNameSilva
person.givenNameMarcia
person.givenNameBranca Maria
person.identifier2017111
person.identifier1033309
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.orcid0000-0001-9884-4751
person.identifier.orcid0000-0002-5610-8024
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
person.identifier.scopus-author-id7005615589
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication26c68872-1849-4895-a48d-72ccffbc02df
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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