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Prevalence of antibiotic (ß-lactams, tetracycline, metronidazole, erythromycin) resistance genes in periodontic infections

2019Journal article Open access
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dc.contributor.authorFreitas, Daniel
dc.contributor.authorGonçalves, Lara
dc.contributor.authorCoelho, Maria João
dc.contributor.authorFerraz, Maria Pia
dc.contributor.authorMagalhães, Ricardo
dc.contributor.authorPina, Cristina Maria San Román Gomes de
dc.contributor.authorCardoso, Inês Lopes
dc.date.accessioned2020-03-02T16:01:05Z
dc.date.available2020-03-02T16:01:05Z
dc.date.issued2019
dc.date.updated2020-02-28T16:04:06Z
dc.description.abstractObjective: Porphyromonas gingivalis and Prevotella intermedia are thought to be pathogens in adult periodontitis. Antibiotherapy is usually needed in the treatment of periodontitis being often prescribed empirically. To allow prescription of a specific antibiotic treatment, identification of resistance genes should be performed. The aim of this study was the identification of the presence of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in previously identified P. intermedia and P. gingivalis isolated from samples collected from periodontal infections. Method: PCR was used for the identification of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in strains isolated from samples collected from periodontal infections. Results: It was seen that 8% of isolates had one of the tested tetracycline resistance genes. A total of 32% of β-lactamases resistance genes was observed in isolated strains. It was also observed that 2% of isolates had one of the analysed erythromycin resistance genes. None of the isolates showed the presence of the metronidazole resistance gene. Conclusions: Most strains harboring β-lactamase resistance genes had been previously identified as P. intermedia. No tetracycline resistance gene and a very low percentage of β-lactamase resistance genes were observed in P. gingivalis strains.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.15761/CRT.1000280pt_PT
dc.identifier.issn2059-0377
dc.identifier.slugcv-prod-812886
dc.identifier.urihttp://hdl.handle.net/10284/8588
dc.language.isoengpt_PT
dc.subjectAntibiotic resistance genespt_PT
dc.subjectPeriodontic infectionspt_PT
dc.subjectβ-lactamasept_PT
dc.subjectTetracyclinept_PT
dc.subjectMetronidazolept_PT
dc.subjectErythromycinpt_PT
dc.titlePrevalence of antibiotic (ß-lactams, tetracycline, metronidazole, erythromycin) resistance genes in periodontic infectionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleClinical Research and Trialspt_PT
oaire.citation.volume5pt_PT
person.familyNameCoelho
person.familyNameFerraz
person.familyNameMagalhães
person.familyNameSan Román Gomes de Pina
person.familyNameLopes Cardoso
person.givenNameMaria João
person.givenNameMaria Pia
person.givenNameRicardo
person.givenNameCristina Maria San Román Gomes de Pina
person.givenNameInês
person.identifier.ciencia-idB118-A25F-32C2
person.identifier.ciencia-id7F16-B2FB-9AD4
person.identifier.ciencia-id5012-F368-BB0C
person.identifier.ciencia-id5D11-7378-444A
person.identifier.ciencia-idF21F-16B4-3715
person.identifier.orcid0000-0002-9169-7776
person.identifier.orcid0000-0002-0274-106X
person.identifier.orcid0000-0002-0723-8359
person.identifier.orcid0000-0002-3880-4712
person.identifier.orcid0000-0002-0693-9831
person.identifier.ridM-6316-2013
person.identifier.ridB-5427-2017
person.identifier.ridM-7156-2013
person.identifier.scopus-author-id55758871700
person.identifier.scopus-author-id7102012951
person.identifier.scopus-author-id6603813413
person.identifier.scopus-author-id54973754300
rcaap.cv.cienciaidF21F-16B4-3715 | Maria Inês de Avelar Lopes Cardoso
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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