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Miconazole-loaded Nanostructured Lipid Carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity

2013-11Journal article Unknown
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dc.contributor.authorMendes, A.I.
dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorCatita, José
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorGabriel, C.
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2020-10-15T09:45:48Z
dc.date.available2020-10-15T09:45:48Z
dc.date.issued2013-11
dc.date.updated2020-07-24T16:05:49Z
dc.description.abstractMiconazole is a widely used antifungal agent with poor aqueous solubility, which requires the development of drug delivery systems able to improve its therapeutic activity. For this purpose, a miconazole-loaded nanostructured lipid carriers (NLC) dispersion was prepared and characterized. Further, the dispersion was used to prepare a NLC-based hydrogel formulation proposed as an alternative system to improve the local delivery of miconazole to the oral mucosa. NLC dispersion showed particles in the nanometer range (≈200 nm) with low polidispersity index (<0.3), good physical stability and high encapsulation efficiency (>87%). A controlled miconazole release was observed from NLC and NLCbased hydrogel formulations, in contrast to a commercial oral gel formulation, which demonstrated a faster release. Additionally, it was observed that the encapsulation of miconazole in the NLC improved its antifungal activity against Candida albicans. Therefore, it was demonstrated that the encapsulation of miconazole in NLC allows for obtaining the same therapeutic effect of a commercial oral gel formulation, using a 17-fold lower dose of miconazole.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.colsurfb.2013.05.041pt_PT
dc.identifier.eid2-s2.0-84882791479
dc.identifier.issn0927-7765
dc.identifier.slugcv-prod-336990
dc.identifier.urihttp://hdl.handle.net/10284/9061
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectMiconazolept_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectOral mucosapt_PT
dc.subjectHydrogelpt_PT
dc.subjectControlled releasept_PT
dc.subjectAntifungal activitypt_PT
dc.titleMiconazole-loaded Nanostructured Lipid Carriers (NLC) for local delivery to the oral mucosa: improving antifungal activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage763pt_PT
oaire.citation.startPage755pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume111pt_PT
person.familyNameSilva
person.familyNameMorais Catita
person.familyNameCerqueira
person.familyNameLopes
person.givenNameAna Catarina
person.givenNameJose Antonio
person.givenNameFátima
person.givenNameCarla
person.identifier953153
person.identifierJose Catita
person.identifier812695
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.ciencia-idB41E-3287-E706
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-6923-0232
person.identifier.orcid0000-0001-7270-5702
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridF-1875-2017
person.identifier.ridM-7557-2013
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id57028697500
person.identifier.scopus-author-id6507275921
person.identifier.scopus-author-id6603346911
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication24bb2971-32ae-429b-b397-145dacb66a5a
relation.isAuthorOfPublication2705e35c-97f6-4de2-bbf1-d680342760e9
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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