Trace minerals in human health: iron, zinc, copper, manganese and fluorine

Silva, Carla Sousa e; Moutinho, Carla; Ferreira da Vinha, Ana; Matos, Carla

Publication

Trace minerals in human health: iron, zinc, copper, manganese and fluorine

2019-09Journal article

dc.contributor.author	Silva, Carla Sousa e
dc.contributor.author	Moutinho, Carla
dc.contributor.author	Ferreira da Vinha, Ana
dc.contributor.author	Matos, Carla
dc.date.accessioned	2019-10-03T16:33:48Z
dc.date.available	2019-10-03T16:33:48Z
dc.date.issued	2019-09
dc.description.abstract	Trace elements exist in the environment in small amounts but play an essential part in sustaining various physiological and metabolic processes occurring within living tissues, as enzymes structure and function, bone and blood maintenance, immune responses or transmission of nerve impulses. They must be obtained from diet, being a varied and balanced diet important for obtaining a series of elements necessary for our body. The total amount of a mineral in a food that is dependent on digestion, its release from the food matrix and the absorption rate by the intestinal cells. If minerals are not supplied in adequate quantities, signs and symptoms of trace elements deficiencies appear. Beyond the nutritional aspects, trace elements have applications in the pharmaceutical industry, integrating pharmacologically active compounds. Usually, in the form of metal complexes, these metal-based drugs are used as anticancer therapeutics, antiinflammatories, antidiabetic drugs or antimicrobial agents. This evolving field is developing metal complexes with remarkable actions, and new metal-based drugs are emerging every year. This article aims to review the main effects of trace elements in human health, namely iron, zinc, copper, manganese and fluorine, focusing on the physiopathology and consequences of lack or excess of these elements. Also, it offers an overview of research information published in recent years concerning the use of these metals in compounds that show promising pharmacological activities.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.issn	2454-2008
dc.identifier.uri	http://hdl.handle.net/10284/8105
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Human Journals	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Trace elements	pt_PT
dc.subject	Human health	pt_PT
dc.subject	Metal-based drugs	pt_PT
dc.subject	Nutrition	pt_PT
dc.title	Trace minerals in human health: iron, zinc, copper, manganese and fluorine	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	80	pt_PT
oaire.citation.issue	3
oaire.citation.startPage	57	pt_PT
oaire.citation.title	International Journal of Science and Research Methodology	pt_PT
oaire.citation.volume	13	pt_PT
person.familyName	Silva
person.familyName	Moutinho
person.familyName	Mendes Ferreira da Vinha
person.familyName	Matos
person.givenName	Carla
person.givenName	Carla
person.givenName	Ana Cristina
person.givenName	Carla
person.identifier	1536969
person.identifier.ciencia-id	2E1D-05DF-E0DB
person.identifier.ciencia-id	B61F-F356-80C6
person.identifier.ciencia-id	011A-FCBD-DC66
person.identifier.ciencia-id	721C-DA34-256E
person.identifier.orcid	0000-0001-6467-4766
person.identifier.orcid	0000-0003-1310-4696
person.identifier.orcid	0000-0002-6116-9593
person.identifier.orcid	0000-0003-0617-3538
person.identifier.rid	D-8159-2013
person.identifier.rid	M-7142-2013
person.identifier.scopus-author-id	16064733800
person.identifier.scopus-author-id	7004493818
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
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