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Lipid nanoparticle mediated drug delivery for safer cancer treatment: example of paclitaxel

2009Journal article Open access
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dc.contributor.authorDoktorovova, Slavomira
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorSouto, Eliana B.
dc.date.accessioned2010-02-23T15:05:19Zpor
dc.date.accessioned2011-10-06T14:52:48Z
dc.date.available2010-02-23T15:05:19Zpor
dc.date.available2011-10-06T14:52:48Z
dc.date.issued2009por
dc.description.abstractOs vectores coloidais de natureza lipídica têm atraído particular atenção para o desenvolvimento de terapias mais seguras e eficazes aplicadas a várias doenças. As vantagens da utilização das nanopartículas lipídicas são exemplificadas utilizando o paclitaxel, um anticancerígeno particularmente interessante para o desenvolvimento de novas formas farmacêuticas mais adequadas para o tratamento do cancro. De facto, este fármaco apresenta problemas de insolubilidade aquosa e sérios efeitos secundários concomitantes à administração da forma farmacêutica convencional (Taxol). Este artigo apresenta uma revisão das razões para a reformulação do paclitaxel e sumariza as vantagens de novas formas farmacêuticas contendo nanopartículas lipídicas para a administração deste anticancerígeno. Colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. The advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. Paclitaxel is known for its water insolubility and serious side effects when administered by its conventional formulation (Taxol). This paper reviews the reasons of further re-formulation of Paclitaxel and summarizes the achievements of lipid nanoparticle-based formulations of this drug.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 6 (2009) 84-93.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/1272por
dc.language.isoengpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries6por
dc.subjectNanopartículas de lípidos sólidospor
dc.subjectVectores lipídicos nanoestruturadospor
dc.subjectNanopartículas lipídicaspor
dc.subjectPaclitaxelpor
dc.subjectTratamento do cancropor
dc.subjectSolid lipid nanoparticlespor
dc.subjectNanostructured lipid carrierspor
dc.subjectLipid nanoparticlespor
dc.subjectPaclitaxelpor
dc.subjectCancer treatmentpor
dc.titleLipid nanoparticle mediated drug delivery for safer cancer treatment: example of paclitaxelpor
dc.typejournal article
dspace.entity.typePublication
person.familyNameDoktorovova
person.familyNameLopes
person.familyNameSouto
person.givenNameSlavomira
person.givenNameCarla
person.givenNameEliana B.
person.identifier.ciencia-id901D-160C-633E
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.orcid0000-0001-5607-0241
person.identifier.orcid0000-0001-5080-032X
person.identifier.orcid0000-0002-9737-6017
person.identifier.ridC-5890-2008
person.identifier.ridM-4689-2016
person.identifier.ridL-9813-2014
person.identifier.scopus-author-id26645513700
person.identifier.scopus-author-id26649517700
person.identifier.scopus-author-id8839435500
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication890a7977-2e87-40e7-928c-d4b77a081345
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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FCS - Número 06 (2009)