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A note on regulatory concerns and toxicity assessment in Lipid-Based Delivery Systems (LDS)

2009-08-01Journal article Restricted access
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dc.contributor.authorSouto, Eliana B.
dc.contributor.authorMartins-Lopes, Paula
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorGaivão, Isabel
dc.contributor.authorSilva, Amélia M.
dc.contributor.authorGuedes-Pinto, Henrique
dc.date.accessioned2020-09-29T11:30:13Z
dc.date.available2020-09-29T11:30:13Z
dc.date.issued2009-08-01
dc.date.updated2020-07-24T17:26:58Z
dc.description.abstractLipid-based Delivery Systems (LDS) has been the focus of potential strategies in drug delivery for several years. A great deal of work has been invested on how to exploit their biocompatible and biodegradable nature, in combination with their nanosize range in a profitable way in the field of nanomedicines. A number of drugs loaded in LDS have been already tested in vivo successfully. However, in vivo behaviour of nanosized materials differs from their bulk counterparts (and also change drug properties), mainly depending on the particular LDS physicochemical characteristics. These may have huge impact on the toxicity of the system, despite the physiological nature of the lipid materials. This note on the regulatory concerns and toxicity assessment in LDS suggests that current knowledge of public and scientific communities is lacking, requiring intensive research and policy measures to provide a deep understanding on toxicological risks.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1166/jbn.2009.1041pt_PT
dc.identifier.eid2-s2.0-70450163722
dc.identifier.issn1550-7033
dc.identifier.slugcv-prod-337005
dc.identifier.urihttp://hdl.handle.net/10284/9007
dc.language.isoengpt_PT
dc.subjectLipid-Based Delivery Systemspt_PT
dc.subjectLDSpt_PT
dc.subjectToxicitypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectLipid Materialspt_PT
dc.subjectNanoparticlespt_PT
dc.titleA note on regulatory concerns and toxicity assessment in Lipid-Based Delivery Systems (LDS)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage322pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage317pt_PT
oaire.citation.titleJournal of Biomedical Nanotechnologypt_PT
oaire.citation.volume5pt_PT
person.familyNameSouto
person.familyNameLopes
person.givenNameEliana B.
person.givenNameCarla
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0002-9737-6017
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridL-9813-2014
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id8839435500
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb9f031fa-7f68-4196-b9c6-9f17cd542f12
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryb9f031fa-7f68-4196-b9c6-9f17cd542f12

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