Repository logo
 
Publication

Lipid nanoparticles for the delivery of biopharmaceuticals

2015Journal article Restricted access
Simple item page
dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorAmaral, M.H.
dc.contributor.authorLobo, J.M. Sousa
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2020-09-29T17:00:58Z
dc.date.available2020-09-29T17:00:58Z
dc.date.issued2015
dc.date.updated2020-07-24T15:34:58Z
dc.description.abstractBiopharmaceuticals comprise therapeutic protein-based, nucleic acids and cell-based products. According to their therapeutic success, the clinical use of these products has been growing. Therefore, the development of efficient biopharmaceuticals delivery systems, which overcome their limitations for administration, remains an excellent prospect for pharmaceutical technologists. In this area, lipid nanoparticles have been increasingly recognized as one of the most promising delivery systems, due to their exclusive advantages. However, no clinical biopharmaceutical lipid nanoparticle-based products are yet available. This fact could be explained by the lack or failure of in vivo studies, regarding stability and toxicological concerns, and also by the complex regulatory issues that must be accomplished. The present review article focuses on the different classes of biopharmaceuticals, their characteristics and limitations for administration. A state of the art regarding the use of lipid nanoparticles to improve biopharmaceuticals delivery is presented and a critical prospect of the future directions that should be addressed by pharmaceutical technologists is also discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1389201015666141229103709pt_PT
dc.identifier.eid2-s2.0-84930972194
dc.identifier.issn1389-2010
dc.identifier.slugcv-prod-1252825
dc.identifier.urihttp://hdl.handle.net/10284/9014
dc.language.isoengpt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectBiopharmaceuticalspt_PT
dc.subjectLipid nanoparticlespt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectNucleic acidspt_PT
dc.subjectPeptidespt_PT
dc.subjectProteinspt_PT
dc.subjectsolid lipid nanoparticlespt_PT
dc.titleLipid nanoparticles for the delivery of biopharmaceuticalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage302pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage291pt_PT
oaire.citation.titleCurrent Pharmaceutical Biotechnologypt_PT
oaire.citation.volume16pt_PT
person.familyNameSilva
person.familyNameLopes
person.givenNameAna Catarina
person.givenNameCarla
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-6923-0232
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridF-1875-2017
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id57028697500
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Current_Pharmaceutical_Biotechnology_2015_16(4).pdf
Size:
1.59 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.64 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS (DCF) - Artigos em Revistas Científicas Internacionais com Arbitragem Científica