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Cyclodextrin-based carriers for topical delivery of anti-inflammatory agents

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dc.contributor.authorOliveira, Rita
dc.contributor.authorBarata, Pedro
dc.date.accessioned2022-01-27T13:03:22Z
dc.date.available2022-01-27T13:03:22Z
dc.date.issued2011
dc.description.abstractAnti-inflammatory agents topically applied are appropriate in the treatment of skin diseases, restricting the therapeutical action to the affected area and reducing systemic side effects. On the other hand, systemic activity is the aim of transdermal delivery, which can be used to minimize the first pass metabolism but also to control systemic side effects, e.g., nonsteroidal anti-inflammatory drugs. The main limitation of this route is to overcome the stratum corneum, the outermost skin barrier. In order to achieve therapeutic concentrations and to improve the drug flux, permeation enhancers are used to optimize drug permeation through the skin. Cyclodextrins and their derivatives are capable of forming inclusion complexes with poor water soluble drugs improving their water solubility, bioavailability and stability, among other features. Cyclodextrins have been used as permeation enhancers although their mechanism it not yet well known. They can also be useful in the design of new drug carriers for skin delivery, by increasing the solubility of drugs hence providing high drug content systems. Improving the drug stability and promoting drug permeation are also desirable properties that cyclodextrins can provide to novel drug carriers. Several anti-inflammatory drugs have been incorporated into various skin delivery cyclodextrin-based systems such as liposomes, solid lipid nanoparticles and microemulsions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1871523011109030230pt_PT
dc.identifier.issn1871-5230
dc.identifier.urihttp://hdl.handle.net/10284/10671
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectTopical deliverypt_PT
dc.subjectTransdermal deliverypt_PT
dc.subjectCyclodextrinspt_PT
dc.subjectLiposomespt_PT
dc.subjectMicroemulsionspt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectComplexationpt_PT
dc.subjectDelivery systemspt_PT
dc.titleCyclodextrin-based carriers for topical delivery of anti-inflammatory agentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage239pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage230pt_PT
oaire.citation.titleAnti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistrypt_PT
oaire.citation.volume10pt_PT
person.familyNameOliveira
person.familyNameBarata
person.givenNameRita
person.givenNamePedro
person.identifier1143078
person.identifier.ciencia-id371C-F327-9C9C
person.identifier.ciencia-id1A18-987D-45C3
person.identifier.orcid0000-0003-0258-9472
person.identifier.orcid0000-0002-4537-5450
person.identifier.scopus-author-id55974811800
person.identifier.scopus-author-id55043534700
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeec36871-71b7-4563-b864-3595628f7194
relation.isAuthorOfPublication8d0c119d-146f-4548-9e03-b16d0050ef08
relation.isAuthorOfPublication.latestForDiscoveryeec36871-71b7-4563-b864-3595628f7194

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