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Cannabis for chronic pain: mechanistic insights and therapeutic challenges

2025-01-15Journal article Open access
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dc.contributor.authorMatos, Carla
dc.contributor.authorPereira, Ana Teresa
dc.contributor.authorDias, Maria João
dc.contributor.authorSilva, Carla Sousa e
dc.contributor.authorFerreira da Vinha, Ana
dc.contributor.authorCarvalho, Márcia
dc.date.accessioned2025-01-20T12:58:10Z
dc.date.available2025-01-20T12:58:10Z
dc.date.issued2025-01-15
dc.description.abstractChronic pain represents a complex and debilitating condition that affects millions of people worldwide, significantly compromising their quality of life. The conventional approach to treating this type of pain often relies on the use of opioid analgesics and anti-inflammatory drugs. While these agents are effective in the short term, they present several limitations, including the risk of dependence, severe side effects, and, in some cases, ineffectiveness in reducing pain. In this context, medical cannabis has emerged as a promising therapeutic alternative, given its potential ability to relieve pain effectively with a favorable safety profile. This work aims to provide a comprehensive and up-to-date review of the existing literature on the effects of medical cannabis in the treatment of chronic pain. Cannabis sativa contains several pharmacologically active compounds, the most prominent of which are delta-9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), which interact with the body’s endocannabinoid system, thereby modulating the pain response. Clinical evidence has shown that cannabinoids can significantly reduce the intensity of chronic pain, particularly in cases of neuropathy, multiple sclerosis, arthritis, and other painful conditions that are unresponsive to conventional treatments. However, the full integration of medical cannabis into clinical practice faces significant obstacles, including the need for standardized dosing, long-term safety data, and regulatory frameworks. These issues, alongside concerns over adverse effects and drug interactions, must be addressed to unlock the full therapeutic potential of cannabinoids, particularly for chronic pain patients, who endure both physical suffering and the added burden of stress.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatos, C.; Pereira, A.T.; Dias, M.J.; Sousa, C.; Vinha, A.F.; Moutinho, C.; Carvalho, M. Cannabis for chronic pain: mechanistic insights and therapeutic challenges. Stresses 2025, 5, 7. https://doi.org/10.3390/ stresses5010007pt_PT
dc.identifier.doi10.3390/ stresses5010007pt_PT
dc.identifier.issn2673-7140
dc.identifier.urihttp://hdl.handle.net/10284/13445
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2673-7140/5/1/7/pdfpt_PT
dc.subjectCannabis sativapt_PT
dc.subject∆ 9 -tetrahydrocannabinolpt_PT
dc.subjectCannabidiolpt_PT
dc.subjectChronic painpt_PT
dc.subjectEndocannabinoid systempt_PT
dc.subjectAdverse effectspt_PT
dc.subjectDrug interactionspt_PT
dc.titleCannabis for chronic pain: mechanistic insights and therapeutic challengespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage7pt_PT
oaire.citation.titleStressespt_PT
oaire.citation.volume5pt_PT
person.familyNameMatos
person.familyNameSilva
person.familyNameMendes Ferreira da Vinha
person.givenNameCarla
person.givenNameCarla
person.givenNameAna Cristina
person.identifier1536969
person.identifier.ciencia-id721C-DA34-256E
person.identifier.ciencia-id2E1D-05DF-E0DB
person.identifier.ciencia-id011A-FCBD-DC66
person.identifier.orcid0000-0003-0617-3538
person.identifier.orcid0000-0001-6467-4766
person.identifier.orcid0000-0002-6116-9593
person.identifier.ridD-8159-2013
person.identifier.scopus-author-id7004493818
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd4b6d3e1-6d29-4fb4-97c7-abb2cf4c83b4
relation.isAuthorOfPublication741eff47-ffdf-4a5f-b763-3ada0062b1b8
relation.isAuthorOfPublicationb09696c0-d5ea-4218-a5e4-63a3f6288d83
relation.isAuthorOfPublication.latestForDiscoveryd4b6d3e1-6d29-4fb4-97c7-abb2cf4c83b4

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