Nanocarrier possibilities for functional targeting of bioactive peptides and proteins:state-of-the-art

Moutinho, Carla; Matos, Carla; Teixeira, José A.; Balcão, Victor

http://hdl.handle.net/10284/8334

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J. Drug Targeting 2011.pdf		1.29 MB	Adobe PDF	Download

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Abstract(s)

This review attempts to provide an updated compilation of studies reported in the literature pertaining to production of nanocarriers encasing peptides and/or proteins, in a way that helps the reader direct a bibliographic search and develop an integrated perspective of the subject. Highlights are given to bioactive proteins and peptides, with a special focus on those from dairy sources (including physicochemical characteristics and properties, and biopharmaceutical application possibilities of e.g. lactoferrin and glycomacropeptide), as well as to nanocarrier functional targeting. Features associated with micro- and (multiple) nanoemulsions, micellar systems, liposomes and solid lipid nanoparticles, together with biopharmaceutical considerations, are presented in the text in a systematic fashion.

Keywords

Animals Dairy Products Drug Administration Routes Drug Carriers Drug Delivery Systems Emulsions Humans Liposomes Micelles Nanoparticles Peptides Proteins