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Células estaminais dentárias e regeneração dentária: revisão narrativa
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Abstract(s)
A regeneração dentária baseia-se no uso de materiais, que têm que permitir o funcionamento adequado da dentição. A eficácia e durabilidade das terapias usadas é questionável, sendo necessários métodos biológicos alternativos que possibilitem um equilíbrio entre a formação do novo tecido dentário e as funções fisiológicas do dente. Diferentes tipos de células estaminais e novos métodos biológicos, têm sido aplicados na pesquisa de regeneração dentária. As células estaminais dentárias são cada vez mais uma fonte dessas pesquisas. Face à complexidade e inovação do tema, o presente trabalho teve como objetivo realizar uma revisão narrativa sobre o estado de arte na utilização de células estaminais dentárias na reparação ou regeneração total dos dentes permanentes. Mantêm-se desafios significativos como a integração sinérgica de sinais estruturais e moléculas biológicas relevantes, tamanho e forma anatómica da coroa, formação de um periodonto adequado e complicações que podem ocorrer durante ou após o transplante.
Dental regeneration is based on the use of materials, which have to allow proper functioning of the dentition. The effectiveness and durability of the therapies used are questionable, and alternative biological methods are needed, allowing a balance between the formation of new tooth tissue and the physiological functions of the tooth. Different types of stem cells and new biological methods have been applied in tooth regeneration research. Dental stem cells are increasingly becoming a source of such research. In view of the complexity and innovation of the topic, the present work aimed to conduct a narrative review on the state of the art in the use of dental stem cells in the repair or total regeneration of permanent teeth. Significant challenges remain such as the synergistic integration of relevant structural signals and biological molecules, size and anatomical shape of the crown, formation of an adequate periodontium, and complications that may occur during or after transplantation.
Dental regeneration is based on the use of materials, which have to allow proper functioning of the dentition. The effectiveness and durability of the therapies used are questionable, and alternative biological methods are needed, allowing a balance between the formation of new tooth tissue and the physiological functions of the tooth. Different types of stem cells and new biological methods have been applied in tooth regeneration research. Dental stem cells are increasingly becoming a source of such research. In view of the complexity and innovation of the topic, the present work aimed to conduct a narrative review on the state of the art in the use of dental stem cells in the repair or total regeneration of permanent teeth. Significant challenges remain such as the synergistic integration of relevant structural signals and biological molecules, size and anatomical shape of the crown, formation of an adequate periodontium, and complications that may occur during or after transplantation.
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Keywords
Reparação dentária Regeneração dentária Células estaminais dentárias Engenharia celular Dental repair Dental regeneration Dental stem cells Cell engineering