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- Antispasmodic activity of aqueous extracts from Mentha x piperita native from Trás-os-Montes region (Portugal)Publication . Moutinho, Carla; Matos, Carla; José Manuel, Neves; Teixeira, Dora Martins; Cunha, Sílvia; Gomes, Lígia RebeloThe wild mint Mentha x piperita (Mentha rotundifolia Huds.), has been used by the local people in a northern region of Portugal to prepare infusions for treating digestive pain and spasms, as an appetite stimulant and for treating headache and migraine. This suggests that these aqueous extracts have analgesic; antispasmodic and stomachic properties. In the present study the antioxidant potential of aqueous extracts of Mentha x piperita is investigated since natural antioxidants can scavenge the reactive oxygen species, ROS, and thus might attenuate inflammation pathways. The antispasmodic activity was also checked. The antioxidant potential of the extract was evaluated by the DPPH• method, by the quantification of the total phenolic compounds and by characterization of the main phenolic compounds. The antispasmodic effects were investigated by performing pharmacological assays using the distal ileum of guinea pigs. The aqueous extract exhibits antioxidant properties that may be due to its phenolic content. The main phenolic compounds were quinic, caffeic, rosmarinic and chlorogenic acids. The antispasmodic affects are observed after electrical stimulation of segments of distal ileum of guinea pigs and may be attributed, at least, to a alfa-1 blockage.
- Actividade antioxidante e avaliação in vitro da citotoxicidade de extractos aquosos de folhas de mentha x piperitaPublication . Neves, José Manuel Gomes da Silva; Matos, Carla; Moutinho, Carla; Gomes, Lígia Rebelo; Teixeira, TâniaNeste estudo apresentam-se os resultados referentes à avaliação do potencial anti-oxidante de extractos aquosos de Menta x piperita recolhida da região de trás-os-montes. A capacidade anti-oxidante foi testada pelo método DppH•, tendo sido também feita a quantificação dos compostos fenólicos totais nos extractos pelo método de Folin-ciocalteu, apontados como os responsáveis pelas propriedades antioxidantes da planta. Adicionalmente, apresentam- se os resultados relativos à avaliação citotoxicidade dos mesmos extractos através de testes de citotoxicidade in vitro, utilizando como organismo modelo tetrahymena pyriformis (com viabilidade avaliada pelo ensaio colorimétrico mtt). The aim of the present study is to investigate the antioxidant potential of aqueous extracts of Menta x piperita from trás-os-montes by the DppH• method, as well as to quantify the total phenolic compounds in the extracts by the Folin-ciocalteu method, probably responsible for the plant antioxidant properties. Additionally, the research work presented herein seeks to assess the effects of Menta x piperita through a series of in vitro cytotoxicity tests, using tetrahymena pyriformis as model organism. Viability will be evaluated by the colorimetric mtt assay.