Revista da Faculdade de Ciências da Saúde
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- Sindrome de sjögren: da imunologia à terapia genéticaPublication . Silva, António Pedro; Felino, Eurico MeloSjögren`s syndrome (SS) is a chronic inflammatory disease with major immunological features that include infiltration of salivary and lacrimal glands by CD4+ T cells and B cells, the presence of autoantibodies to nucleoproteins and its genetic predisposition linked to the HLA region. It`s diagnosis can be made using different criteria approved by WHO. Recent advances in the field of genetic therapy opens new perspectives for the treatment of SS – the use of genes encoding for anti-inflamatory cytokines is being studied.
- Terceira dentição natural, será possível?Publication . Silva, António Pedro; Dias, Nuno Sousa; Cardoso, Inês LopesThe main goal of this work is to present some of the most notorious advances in Dental Medicine, which will probably change greatly the practice of this job. We emphasize the importance of stem cells and molecular biology in the development of dental tissues, teeth in the laboratory and teeth inside the mouth. Some of the research groups involved in these subjects are mentioned, as well as some relevant studies and their future impact in Dentistry.
- Proteínas dentinogénicas: o material ideal para pulpotomiasPublication . Costa, Maria Esmeralda A. G. Ribeiro daThe pulpotomy technique consists in the extirpation of the coronary pulp and in the placement, in the entrance of the root canals, of a material that protects and preserves the vitality of the remaining pulp in the root. With that purpose, many pulp capping materials have been proposed, as the formocresol, glutaraldehyde, calcium hydroxide and more recently, the morphogenetic proteins. The aim of this work was the study of the action and use of those proteins, capable to induce the dentin formation, while capping agents of pulpar stumps in the pulpotomy.
- Hipersensibilidade do sistema imune e patologias da mucosa oralPublication . Barros, Liliana; Ribeiro, SofiaAn overreaction of the immune system to both infectious and inert antigens can lead to severe tissue damage. These hypersensitivity reactions are classified into four main types depending of the response-immediate or delayed and of the immune component involved. In this article we provide some evidences of the role of immunological mechanisms in type I and type IV hypersensitivity trough a relation with oral pathologies known has Contact Stomatitis and Oral Lichen Planus.
- Restaurações de fracturas coronárias de dentes anterioresPublication . Melo, Paulo; Domingues, Joana; Teixeira, Liliana; Manarte-Monteiro, Patricia; Monteiro, BeatrizNowadays crown fractures of anterior teeth are getting more common in children and teenagers. These kinds of accidents can affect them for the rest of them lives, behalf of their age, gender or socioeconomic status. This is one of the reasons why dentists are always trying to find different solutions for the treatment of these cases. Mainly in anterior teeth fractures involving enamel or enamel and dentin, one has the direct restoration solution, using composite resin. In this case, the introduction of the “self-etch” technique, and the evolution of adhesive systems and the better physical and aesthetic behaviour of the composite resins, lead to better results. Thus, one can consider the direct restoration as a valid solution that can be done quickly and still is aesthetic and as an excellent clinical behaviour. The authors present a clinical case of an extended traumatic fracture treated with a micro-hibrid composite resin.
- A requirement for the abnormal spindle protein to organise microtubules of the central spindle for cytokinesis in drosophilaPublication . Riparbelli, Maria Giovanna; Callaini, Giuliano; Glover, David M.; Avides, Maria do CarmoDrosophila abnormal spindle (asp) mutants exhibit a mitotic metaphase checkpoint arrest with abnormal spindle poles, which reflects a requirement for Asp for the integrity of microtubule organising centres. In male meiosis, the absence of a strong spindle integrity checkpoint enables asp mutant cells to proceed through telophase. However, the central spindle region is not correctly organised and cells frequently fail to complete cytokinesis. We speculate that Asp is associated with the minus ends of microtubules that have been released from the spindle poles to form the central spindle.
- Processos automáticos de titulação baseados em sistemas discretos e de fluxo – evolução ao longo dos temposPublication . Moutinho, Carla; Matos, Carla; Almeida, Cristina; Balcão, VictorThe continuous necessity of create new analytical methods and to adapt them to the increasing demands of control and monitoring have promote the appearance and development of many areas of analytical chemistry, as well as the interest about automatization of methods of analysis. Automatic methods of analysis had assumed a great importance, namely, in clinical chemistry and in a level of the environmental control. The automatic needs pass, also, for the titrations, as a result of a crescent search for this king of analysis in samples of different origins. So, in this article is doing a revision about the titration systems (discrete and automatic) described, until date, in the literature.
- Moléculas anfifílicas - lípidos - e formação de agregados supramoleculares: micelas e lipossomasPublication . Moutinho, Carla; Matos, Carla; Almeida, Cristina; Balcão, VictorThe ability for self-organization of amphiphilic molecules (lipids), forming structurally more complex systems, from micelles to liposomes, constitutes the basic foundation for many biological phenomena. Lipids, for presenting important physiological roles, correlated with their particular structure and self-aggregation properties, are an interesting field of research and development. A detailed study of the micellar and membranar environment is fundamental to the knowledge of micelle´s and liposome´s capacity of acting as solubilization enhancers, what would allow the gathering of valuable information about drug´s mechanisms of transportation throw biomembranes. Assessment of the multiple amphiphilic molecule´s characteristics, together with the evaluation of the organized structures formed, is of the best interest for the comprehension of certain physiological functions, namely absorption, distribution and dynamics of certain compounds in the human organism.
- Caracterização de modelos biomembranares (micelas e lipossomas) para a determinação de coeficientes de partiçãoPublication . Matos, Carla; Moutinho, Carla; Almeida, Cristina; Balcão, VictorA drug´s mechanism of action is dependent and related to its chemical structure and, in the bottom line, to the ability of the structure to interact with biological systems. The phospholipid composed cell membrane is a particularly important system for the pharmacological action of a drug, hence pharmacokinetic parameters are generally related with the drug/membrane interaction. This interaction is dependent on the hydrophilic/lipophilic balance of the drug, a parameter traditionally assessed by the organic solvent/water partition coefficient. Liposomes and micelles, due to their composition and physical organization, can constitute basic structural models for the cell membrane, being a precious tool in drug/membrane interaction studies. The use of these simpler models allows for the comprehension of basic processes, from which a progressive complexity can be added to the system, for a progressive insight of the involved phenomena. In this context, the determination of the liposome/water, or micelle/water partition coefficients, can constitute an indicative parameter of the drug´s real behaviour in the biological system.
- Um tratamento postural para a dislexia?Publication . Almeida, Alexandre Frey Pinto deDyslexia is a specific reading disability which requires namely, for a complete diagnosis, the submission to a reading scale and an intelligence scale in the context of an attentive medical and psychological examination. This one is supposed to confirm objectively the reading difficulties and to exclude such possible aetiologies as developmental disturbances of any other nature, sensorial deficit, neurological / psychiatric diseases or main problems in school. Nevertheless, dyslexia often occurs accompanied by dysortography and many neurological “soft-signs”. Pinto de Almeida (1993) also noticed a frequent association with Postural Deficit Syndrome, and this author’s working hypothesis is being supported by new evidence: it seems now to be confirmed that the treatment of the associated PDS by means of postural reprogramming and the use of low potency prismatic lenses may obtain very considerable effects on the reading performance itself. As a matter or fact, G. Serrano and O. Alves da Silva (1998) related very similar results in a great number of dysortographic children, possibly dyslexic ones, arguing that this is the main treatment for most cases, and assuming that the enhancement is due to the correction of proprioceptive dysfunctions caused by vicious positions leading to a cognitive inhibition which could make reading something very hard to do. The author criticises that way of thinking and claims for another conception of dyslexia and even the associated PDS, that could both be seen as “dyslaterality syndromes”, depending on the same general hemispheric function disharmony. Not only this new postural treatment but other performant interventions as well could potenciate each other in order to improve the peculiar neurological background of that syndromatic constellation.