Browsing by Author "Sellam, Adam Daniel"
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- Hydrogel-based systems used in dentistry to promote tissue regenerationPublication . Sellam, Adam Daniel; Pereira, Carla Patrícia FernandesOral diseases represent a serious and growing worldwide public health, becoming a pronounced challenge in developed and developing countries. Numerous treatments are already well-established in dentistry in order to treat a vast range of pathologies. Still, the use of effective materials prompting the fast and improved predictability of dental tissue regeneration with a minimization of surgical errors/side effects and an enhanced operational flow is still restricted. To overcome these limitations, the development of new materials capable of being used as synthetic extracellular matrices in tissue regeneration with good biocompatibility, biodegradability, and flexible mechanical properties is mandatory. In this context, the hydrogel-based systems have been established as promising materials that exhibit the mentioned features, being effective in mimetizing the native cell microenvironment. This narrative review focuses on the systematization/analysis of the hydrogel-based systems capabilities in dentistry to promote tissue regeneration – periodontal, dental pulp regeneration, and enamel remineralization, being also described the general features of this class of materials – classification, preparation strategies, characterization system, peculiar properties, and general applications. The literature survey was carried out in the PubMed, Scopus, and Web of Science databases using the keywords: "Hydrogel", "Oral tissue", "Dental tissue", "Regeneration", "Tissue regenerative engineering" and "Dentistry" combined with each other with the Boolean operator AND, and OR. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were used, being included in this review a total of ninety one publications after the screening process. The development of hydrogel-based materials acting as carriers in the delivery of stem cells, drugs, and therapeutic agents is an exciting research field, that is still in an early stage in dentistry. These materials exhibit a huge potential in the dental tissue regeneration in modern dental medicine due to their peculiar features and tunable physical and chemical characteristics that allow them to mimetize the extracellular matrix, the release of signal molecules and the regulation of the stem cell behavior. However, the development of easier and more appealing preparation processes from an economic point of view and the lack of robust safety studies to some extent constitute the main issues in translation research from academia to industry.