Browsing by Author "Pinho, Bruna Gabriela Morais"
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- Gut-muscle axis and the development of sarcopenia and frailty: overview on the current evidencePublication . Pinho, Bruna Gabriela Morais; Sousa, Ana Sofia; Simões, CatarinaIntroduction: Aging comprehends physiological and metabolic changes, and, in this process, elderly individuals are more susceptible to develop sarcopenia and frailty. These two conditions that exert a negative impact on the skeletal muscle mass and are mediated by the gut-muscle axis. Aim: To present an update overview on the current evidence regarding the gut-muscle axis hypothesis and the association with the development of sarcopenia and frailty. Results: The occurrence of sarcopenia and frailty comprehends pathogenesis mechanisms related with gut microbiota changes that promote the impairment on the muscle mass. The identification of bacteria species of the gut microbiota is important for establish a profile of the microbiota composition that are present in sarcopenic and/or frailty individuals. Conclusion: There is evidence of a gut-muscle axis in which the muscle quantity and quality is, to a certain extent, mediated by the gut microbiota.