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First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells

2010Journal article Restricted access
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dc.contributor.authorCarvalho, Márcia
dc.contributor.authorSilva, Branca M.
dc.contributor.authorSilva, Renata
dc.contributor.authorValentão, Patrícia
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorBastos, Maria L.
dc.date.accessioned2021-07-02T16:42:09Z
dc.date.available2021-07-02T16:42:09Z
dc.date.issued2010
dc.description.abstractThe present study reports the phenolic profile and antiproliferative properties of quince (Cydonia oblonga Miller) leaf and fruit (pulp, peel, and seed) against human kidney and colon cancer cells. The phenolic profiles of quince methanolic extracts were determined by high-performance liquid chromatography (HPLC)/diode array detector (DAD). 5-O-Caffeoylquinic acid was always one of the two major phenolic compounds present in all extracts, except for seed. Our results revealed that quince leaf and fruit extracts exhibited distinctive antiproliferative activities. The extracts from quince leaf showed concentration-dependent growth inhibitory activity toward human colon cancer cells (IC(50) = 239.7 +/- 43.2 microg/mL), while no effect was observed in renal adenocarcinoma cells. Concerning the fruit, seed extracts exhibited no effect on colon cancer cell growth, whereas strong antiproliferative efficiency against renal cancer cells was observed for the highest concentration assayed (500 microg/mL). The antiproliferative activity of pulp and peel extracts was low or absent in the selected range of extract concentrations. This is the first report showing that C. oblonga may be useful as a cancer chemopreventive and/or chemotherapeutic agent.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1021/jf903836kpt_PT
dc.identifier.eissn1520-5118
dc.identifier.issn0021-8561
dc.identifier.urihttp://hdl.handle.net/10284/10045
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACS Publicationspt_PT
dc.subjectCydonia oblonga Millerpt_PT
dc.subjectQuincept_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectAntiproliferative activitypt_PT
dc.subjectKidney cancerpt_PT
dc.subjectColon cancerpt_PT
dc.titleFirst report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3370pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage3366pt_PT
oaire.citation.titleJournal of Agricultural and Food Chemistrypt_PT
oaire.citation.volume58pt_PT
person.familyNameCarvalho
person.familyNameSilva
person.givenNameMarcia
person.givenNameBranca Maria
person.identifier2017111
person.identifier1033309
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.orcid0000-0001-9884-4751
person.identifier.orcid0000-0002-5610-8024
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
person.identifier.scopus-author-id7005615589
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication26c68872-1849-4895-a48d-72ccffbc02df
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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