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Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)

2017Journal article Restricted access
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dc.contributor.authorAraújo, Ana Margarida
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorCarvalho, Félix
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorGuedes de Pinho, Paula
dc.date.accessioned2021-07-02T15:09:17Z
dc.date.available2021-07-02T15:09:17Z
dc.date.issued2017
dc.description.abstractDrug-induced liver injury (DILI) is a major safety issue during drug development, as well as the most common cause for the withdrawal of drugs from the pharmaceutical market. The identification of DILI biomarkers is a labor-intensive area. Conventional biomarkers are not specific and often only appear at significant levels when liver damage is substantial. Therefore, new biomarkers for early identification of hepatotoxicity during the drug discovery process are needed, thus resulting in lower development costs and safer drugs. In this sense, metabolomics has been increasingly playing an important role in the discovery of biomarkers of liver damage, although the characterization of the mechanisms of toxicity induced by xenobiotics remains a huge challenge. These new-generation biomarkers will offer obvious benefits for the pharmaceutical industry, regulatory agencies, as well as a personalized clinical follow-up of patients, upon validation and translation into clinical practice or approval for routine use. This review describes the current status of the metabolomics applied to the early diagnosis and prognosis of DILI and in the discovery of new potential urinary biomarkers of liver injury.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/10408444.2017.1309638pt_PT
dc.identifier.eissn1547-6898
dc.identifier.issn1040-8444
dc.identifier.urihttp://hdl.handle.net/10284/10036
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationPOCI/01/0145/FEDER/07728pt_PT
dc.relationApplied Molecular Biosciences Unit
dc.subjectDrug-induced liver injurypt_PT
dc.subjectHepatotoxicitypt_PT
dc.subjectMetabolomicspt_PT
dc.subjectUrinary biomarkerspt_PT
dc.subjectConventional biomarkerspt_PT
dc.titleMetabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04378%2F2013/PT
oaire.citation.endPage654pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage638pt_PT
oaire.citation.titleCritical Reviews in Toxicologypt_PT
oaire.citation.volume47pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6
relation.isProjectOfPublication61924098-eb12-4752-9d4a-6e4243fc921d
relation.isProjectOfPublication.latestForDiscovery61924098-eb12-4752-9d4a-6e4243fc921d

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