Lopes, Carla MartinsLobo, José M. SousaPinto, João F.Costa, Paulo C.2020-09-282020-09-282007http://hdl.handle.net/10284/9005The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dualcomponent tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.engBiphasic delivery systemDual-component tabletjournal article2020-07-24cv-prod-337010doi.org/10.1208/pt08030762-s2.0-353488390112-s2.0-35148838685