Moreira, Maria Avides2008-07-162011-10-062008-07-162011-10-062005Revista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 2 (2005) 55-62.1646-0480http://hdl.handle.net/10284/547Every cell in a multicellular organism has the potential to die by apoptosis. Treatment of cancer cells with tumour necrosis factor - can induce an apoptotic signal leading to the death of these cells; however, many malignancies are resistant to the effects of TNF-α. Overexpression of FLIP, a protein that blocks the caspase activity of FLICE, mediates the observed resistance. Thus, FLIP, which normally prevents inappropriate apoptosis, may become a tumour progression factor.Articleengjournal article