The role of lipids in drug absorption throught the GIT

Doktorovova, Slavomira; Morsy, Tarek; Balcão, Victor; Souto, Eliana B.

http://hdl.handle.net/10284/932

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Authors

Doktorovova, Slavomira

Morsy, Tarek

Balcão, Victor

Souto, Eliana B.

Abstract(s)

Os vectores lipídicos apresentam inúmeras vantagens para a administração oral de substâncias farmacológicas, p.ex. são compostos por moléculas lipídicas semelhantes àquelas que figuram nos tecidos humanos, tornando-se biocompatíveis, biotoleráveis e biodegradáveis. São exemplos as tradicionais emulsões O/A, as suspensões de nanopartículas lipídicas (SLNs e NLC s) e, recentemente, as SolEmuls®, que permitem localizar fármacos fracamente solúveis em ambas as fases das emulsões, na camada interfacial de lecitina. Este artigo aborda o papel dos lípidos no aumento da absorção e da biodisponibilidade de fármacos administrados oralmente. Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/w emulsions, suspensions of lipid nanoparticles (SLNs and NLC s) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and aqueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally.

Keywords

Administração oral de fármacos Lipossomas Nanopartículas de lípidos sólidos Vectores lipídicos nanoestruturados Oral drug delivery Liposomes Solid lipid nanoparticles Nanostructured lipid carriers